C-5 HYDROXYETHYL AND HYDROXYPROPYL ACYCLONUCLEOSIDES AS SUBSTRATES FOR THYMIDINE KINASE OF HERPES SIMPLEX VIRUS TYPE 1 (HSV-1 TK): SYNTHESES AND BIOLOGICAL EVALUATION

The efficient syntheses of 5-(2-hydroxyethyl)- and 5-(3-hydroxypropyl)-substituted pyrimidine derivatives bearing 2,3-dihydroxypropyl, acyclovir-, ganciclovir- and penciclovir-like side chains are reported.A synthetic approach that included the alkylation of an N-anionic-5-substituted pyrimidine intermediate (method A) provided the target acyclonuc

This paper researches the fixed-time leader-following consensus problem for nonlinear multi-agent systems (MASs) affected by unknown disturbances under the jointly connected graph.In order to achieve control Chairs - Commode - Shower goal, this paper designs a fixed-time consensus protocol, which can offset the unknown disturbances and the nonlinea

This research aimed to understand the structuring of psychological assessments in custody Video Cables actions and, on the other hand, to identify the existence of homogeneity or heterogeneity in these practices.Twenty-nine Brazilian legal psychologists participated in this study and answered an online questionnaire built based on the literature.Th

Xingfen Su,1 Handong Wang,2 Yuanxiang Lin,1 Fuxiang Chen1 1Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian, People’s Republic of China; 2Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, People’s Republic of China B

This paper considers the role of foreign trade interactions in forming a new macroeconomic equilibrium and equilibrium in the commodity market in the context of massive sanctions.The author analyzes the relations between the tools and conditions for maintaining foreign trade dynamics, and the role and proportion of traditional and new commodity mar